# 'Trial Sequential Analysis' for Error Control and Inference in Sequential Meta-Analyses

## Documentation for package ‘RTSA’ version 0.2.2

- DESCRIPTION file
- User guides, package vignettes and other documentation
- Package README

## Help Pages

boundaries | Boundaries for group sequential designs
coronary | Dataset of trials investigating the intensity of statin therapy on the risk of myocardial infarction or coronary death
eds | Dataset of trials investigating the effect of carer on early supported discharge services
inference | Inference calculations for sequential meta-analysis
metaanalysis | Fixed-effect or random-effects meta-analysis
minTrial | Minimum number of trials needed for a specific level of power
perioOxy | Dataset of RCTs investigating the effect of 80% perioperative oxygen vs. 30 -35% perioperative oxygen on surgical site infection.
plot.boundaries | Plot of boundaries for group sequential designs
plot.metaanalysis | Forestplot for metaanalysis object.
plot.RTSA | Plot RTSA object. Returns the R version of the original TSA plot.
print.metaanalysis | Fixed-effect or random-effects meta-analysis
print.ris | Calculate required sample and trials size.
print.RTSA | R version of Trial Sequential Analysis. Used for designing and analysing sequential meta-analyses.
ris | Calculate required sample and trials size.
RTSA | R version of Trial Sequential Analysis. Used for designing and analysing sequential meta-analyses.